Certification in Clinical Informatics Subspecialty Exam Prep
Free practice questions

Free CI Practice Questions

10 exam-style questions with answers and explanations, straight from our 1,030-question bank. Tap an answer to check yourself. When you're ready, take the scored version in the free practice test.

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The CI exam has 200 questions and runs 4 hours.

These 10 free CI questions are organized by exam domain, so you can see how each part of the Certification in Clinical Informatics Subspecialty blueprint is tested. Reveal the answer and explanation under each question.

Domain 1: Fundamental Knowledge and Skills 20% of exam

Question 1

Since an external laboratory joined a health information exchange, a patient's sodium trend graph has shown abrupt changes between measurements collected minutes apart. Review of the original reports identifies one serum specimen and one random urine specimen, both reported in mmol/L. Patient identifiers, numeric results, and collection times were transmitted correctly. What most likely caused these results to appear in the same clinical trend series?

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Correct answer: B - The terminology mapping collapsed different specimen systems into one concept.

Question 2

An outside cardiologist treating a patient requests prior laboratory results and medication records through a verified secure exchange. The hospital's disclosure gateway releases only the latest summary, citing HIPAA's minimum necessary requirement. The recipient's identity and treatment purpose have been verified; hospital policy permits the disclosure, and no additional legal restriction or agreed restriction applies. Which response is appropriate under the HIPAA Privacy Rule?

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Correct answer: B - Release the requested records; the minimum necessary limitation does not apply to this treatment disclosure.

Domain 2: Improving Care Delivery and Outcomes 30% of exam

Question 3

A medication-duplication warning interrupts prescribing repeatedly during documented transitions between orders whose administration periods do not overlap. Clinical review finds these warnings nonactionable. Warnings for unintended concurrent therapy, however, still prompt useful corrections. The informatics team can reliably distinguish these two situations. Which redesign best preserves the warning's clinical value?

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Correct answer: D - Suppress nonoverlapping-transition warnings while retaining warnings for unintended concurrent therapy.

Question 4

A hospital is estimating the yield of pharmacist review for an acute kidney injury alert. In a fully followed validation cohort of 1,000 adult admissions, 50 patients develop the specified outcome within 48 hours. At the proposed threshold, sensitivity is 80% and specificity is 90%. Each alert-positive patient receives one review. Approximately what proportion of those reviews will concern a patient who develops the outcome?

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Correct answer: A - 30%; most reviewed patients will not develop acute kidney injury.

Question 5

An external validation report for a 30-day readmission model shows an AUROC of 0.88. In three large groups with average predicted risks of 5%, 15%, and 30%, the observed readmission frequencies are 2%, 6%, and 12%, respectively. Follow-up is complete, and confidence intervals around those observed frequencies are narrow. Which conclusion is supported by this combination of findings?

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Correct answer: D - The model discriminates above chance but systematically overestimates absolute risk.

Domain 3: Enterprise Information Systems 15% of exam

Question 6

At 02:15, the incident team confirms active ransomware encryption on EHR servers, and electronic ordering becomes unavailable. Engineers can isolate the affected server segment without disabling bedside equipment. The emergency department is treating critically ill patients; its monitors and pumps remain functional, and staff have rehearsed offline ordering and medication documentation. Which immediate response best balances containment with clinical continuity?

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Correct answer: D - Isolate the affected segment and activate the rehearsed clinical downtime procedures.

Question 7

The pharmacy system commits a new medication order, but its acknowledgment is lost during a network interruption. The sending system retries the unchanged request with the same unique order identifier. The pharmacy system then creates a second active order. Legitimate new orders receive different identifiers. Which receiver behavior would prevent this failure without giving up reliable retries?

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Correct answer: C - Recognize the previously processed identifier and return its existing result without another order.

Domain 4: Data Governance and Data Analytics 15% of exam

Question 8

A ward-deterioration model is intended to generate predictions at 08:00 each day. Retrospective validation yields an AUROC of 0.94 using separate patients for development and testing. The feature query selects laboratory results by specimen collection time: a sample collected at 07:30 is included even when its result first became available in the EHR at 09:30. How should the validation be corrected before interpreting its performance?

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Correct answer: A - Reconstruct predictors from information available in the EHR by 08:00.

Domain 5: Leadership and Professionalism 20% of exam

Question 9

A capitated health system is deciding whether to renew a laboratory-ordering intervention for another year. Continuing it will avoid 10,000 unnecessary tests. Each avoided test saves $4 in purchased supplies; the accounting system also allocates $12 of fixed overhead per test, but total overhead and staffing expenditures will not change. Renewal costs $25,000. Last year's $40,000 implementation payment is nonrecoverable, and revenue will be unchanged. What is the intervention's incremental cash benefit for the coming year, before taxes?

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Correct answer: C - A $15,000 increase in cash.

Question 10

Barcode medication administration has low uptake on a pediatric ward despite strong staff support. Nurses demonstrate the complete workflow correctly in observed simulations. During medication rounds, an observer finds that functioning scanners are repeatedly unavailable because the same carts are assigned elsewhere. The implementation lead has funding for one immediate intervention. Where should that funding go?

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Correct answer: C - Ensure functioning scanners are available at the bedside throughout medication rounds.

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